Bone cancer therapy unexpectedly makes tumours less painful
An artist’s impression of nanomedicine in action ALFRED PASIEKA/SCIENCE PHOTO LIBRARY Cancer that spreads to bones can be deadly, and it also tends to be painful. Now, a drug seems…
Breakthrough cancer therapy stops tumor growth without harming healthy cells
Scientists at the Francis Crick Institute and Vividion Therapeutics have discovered chemical compounds that can precisely prevent the cancer-driving gene RAS from connecting with a key pathway responsible for tumor…
New gene-editing therapy shows early success in fighting advanced GI cancers
Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers. The results, recently…
FDA clears IND for clinical trial testing switchable CAR-T therapy in patients with autoimmune diseases, without chemotherapy
Calibr-Skaggs Institute for Innovative Medicines, the drug discovery division of Scripps Research, announced today that the FDA has cleared their investigational new drug (IND) application to study switchable chimeric antigen…
Mindfulness and cognitive behavioral therapy improve chronic low back pain
The list of treatments for low back pain is endless, but few offer relief for the one in four Americans who suffer from this persistent pain and leading cause of…
Immunotherapy may boost KRAS-targeted therapy in pancreatic cancer
Adding immunotherapy to a new type of inhibitor that targets multiple forms of the cancer-causing gene mutation KRAS kept pancreatic cancer at bay in preclinical models for significantly longer than…
Targeted alpha therapy: Breakthrough in treating refractory skin cancer
Metastatic melanoma, also known as stage IV melanoma, is a type of skin cancer that spreads to other parts of the body. It is one of the most aggressive forms…
New therapy may effectively control HIV in Uganda
A multi-national, multi-institutional study led by Weill Cornell Medicine investigators found little natural resistance to a new HIV therapy called lenacapavir in a population of patients in Uganda. The study,…
Gene therapy for rare epilepsy shows promise in mice
Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death. Most cases…
Microbial therapy offers new hope for vitiligo patients
A natural compound derived from gut-friendly bacteria significantly slows the progression of vitiligo and may restore pigmentation, reports a new Northwestern University pre-clinical study in mice. The findings could offer…